Selected Publications:

Ethell, I.M. and Yamaguchi, Y. 1999. Cell surface heparan sulfate proteoglycan syndecan-2 induces the maturation of dendritic spines in rat hippocampal neurons. J Cell Biol. 144(3):575-586.

Wang, H.-G., Pathan, N., Ethell, I.M., Krajewski, S., Yamaguchi, Y., Shibasaki, F., McKeon, F., Bobo, T., Franke, T.F. and Reed, J. 1999. Ca-Induced apoptosis through calcineurin dephosphorylation of BAD. Science. 284(5412):339-343.

Gartner, A., Shostak, Y., Hackel, N., Ethell, I.M., and Thoenen, H. 2000. Ultrastructural identification of storage compartments and localization of activity-dependent secretion of neurotrophin 6 in hippocampal neurons. Mol Cell Neurosci. 15(3):215-234.

Ethell, I.M., Hagihara, K., Miura, Y., Irie, F. and Yamaguchi, Y. 2000. Synbindin, a novel syndecan-2-binding protein in neuronal dendritic spines. J Cell Biol. 151(1):53-68.

Ethell, I.M., Irie, F., Kao, M.S., Couchman, J.R., Pasquale, E.B. and Yamaguchi, Y. 2001. EphB/syndecan-2 signaling in dendritic spine morphogenesis. Neuron. 31(6):1001-1013.

Henkemeyer, M., Itkis, O.S., Ngo, M., Hickmott, P.W. and Ethell, I.M.. 2003. Multiple EphB receptor tyrosine kinases shape dendritic spines in the hippocampus. J Cell Biol. 163(6):1313-26.

Ethell, I.M. and Pasquale, E.B. 2005. Molecular mechanisms of dendritic spine development and remodeling. Prog. Neurobiol. 75(3):161-205. Epub 2005 Apr 2.

Hoogenraad, C.C., Milstein, A.D., Ethell, I.M., Henkemeyer, M. and Sheng, M. 2005. GRIP1 controls dendrite morphogenesis by regulating EphB receptor trafficking. Nat Neurosci. 8(7):906-915.

Moeller, M.L, Shi, Y., Reichardt, L.F. and Ethell, I.M. 2006. EphB receptors regulate dendritic spine morphogenesis through the recruitment/phosphorylation of FAK and RhoA activation. J Biol Chem. 281(3):1587-1598. Epub 2005 Nov 18.

Shi, Y.and Ethell, I.M. 2006. Integrins Control Dendritic Spine Plasticity in Cultured Hippocampal Neurons through NMDAR/CaMKII Dependent Actin Reorganization. J. Neurosci., 26(6):1813-1822.

Hickmott, P.W. and Ethell, I.M. 2006. Dendritic plasticity in the adult neocortex. Neuroscientist. 12(1):16-28.

Bilousova, T.V., Rusakov, D., Ethell, D.W. and Ethell, I.M. 2006. Matrix Metalloproteinase-7 Disrupts Dendritic Spines in Hippocampal Neurons through NMDA Receptor Activation. J. Neurochem., 97(1):44-56. Epub 2006 Mar 3.

Yang, N.Y., Pasquale, E.B., Owen, L.B. and Ethell, I.M. 2006. The EphB4 receptor-tyrosine kinase promotes the migration of melanoma cells through Rho-mediated actin cytoskeleton reorganization. J Biol Chem., 281(43):32574-32586. Epub 2006 Aug 31.

Ethell, I.M. and Ethell, D.W. 2007. Matrix metalloproteinases in brain development and remodeling: synaptic functions and targets. J. Neorusci Res. 85(13):2813-2823

Carson, M.J., Bilousova T.V., Puntambekar, S.S., Melchior, B., Doose, J.M. and Ethell, I.M. 2007. A rose by any other name? The potential consequences of microglial heterogeneity during CNS health and disease. Neurotherapeutics, 4(4):571-579

Lin, K.T., Sloniowski, S., Ethell, D.W. and Ethell, I.M. 2008. Ephrin-B2-induced cleavage of EphB receptor is mediated by matrix metalloproteinases to trigger cell repulsion. J Biol Chem. 283(43):28969-28979

Bilousova, T.V., Dansie, L., Ngo, M., Aye, J., Charles, J.R., Ethell, D.W. and Ethell, I.M. 2009. Minocycline promotes dendritic spine maturation and improves behavioural performance in the fragile X mouse model. J Med Genet. 46(2):94-102. EpuB 2008 Oct 3.

Pontrello, C.G. and Ethell, I.M. 2009. Accelerators, Brakes and Gears of Actin Dynamics in Dendritic Spines. Open Neurosci J. 3:67-86

Shi, Y., Pontrello, C.G., DeFea, K.A., Reichardt, L.F. and Ethell, I.M. 2009. Focal adhesion kinase acts downstream of EphB receptors to maintain mature dendritic spines by regulating cofilin activity. J Neurosci. 29(25):8129-8142

Yang, N.Y., Lopez-Bergami, P., Goydos, J.S., Yip, D., Walker, A.M., Pasquale, E.B. and Ethell, I.M. 2010. The EphB4 receptor promotes the growth of melanoma cells expressing the ephrin-B2 ligand. Pigment Cell Melanoma Res. 23(5):684-687

Utari, A., Chonchaiya, W., Rivera, S.M., Schneider, A., Hagerman, R.J., Faradz, S.M., Ethell, I.M. and Nguyen, D.V. 2010. Side effects of minocycline treatment in patients with fragile X syndrome and exploration of outcome measures. Am J Intellect Dev Disabil. 115(5):433-43

Paribello, C., Tao, L., Folino, A., Berry-Kravis, E., Tranfaglia, M., Ethell, I.M. and Ethell, D.W. 2010. Open-label add-on treatment trial of minocycline in fragile X syndrome. BMC Neurol. 10:91.

Cesa R, Premoselli F, Renna A, Ethell IM, Pasquale EB, Strata P. 2011. Eph receptors are involved in the activity-dependent synaptic wiring in the mouse cerebellar cortex. PLoS One. 6(4):e19160.

Dansie L, Ethell IM. 2011. Casting a net on dendritic spines: The extracellular matrix and its receptors. Dev Neurobiol. 71(11): 956-981.

Sloniowski S, Ethell IM. 2011. Looking forward to EphB signaling in synapses. Seminars in Cell and Dev Biol. 23(1):75-82.

Rotschafer SE, Trujillo MS, Dansie LE, Ethell IM, Razak KA. 2011. Minocycline treatment reverses ultrasonic vocalization production deficit in a mouse model of Fragile X Syndrome. Brain Res. 1439:7-14.

Pontrello, C.G., Sun, M.-Y., Lin A., Fiacco T.A., DeFea, K.A., Ethell, I.M. 2012. Cofilin under control of beta-arrestin-2 in NMDA-dependent dendritic spine plasticity, long-term depression (LTD), and learning. PNAS, 109(7):E442-451.

Dansie LE, Phommahaxay K, Okusanya AG, Uwadia J, Huang M, Rotschafer SE, Razak KA, Ethell DW and Ethell IM. 2013. Long-lasting Effects of Minocycline on Behavior in Young but not Adult Fragile X Mice. Neuroscience. 246:186-198.

Sidhu H, Dansie LE, Hickmott PW, Ethell DW, Ethell IM. 2014. Genetic Removal of Matrix Metalloproteinase 9 Rescues the Symptoms of Fragile X Syndrome in Mouse Model. J Neuroscience. 34(30):9867-9879.

Reinhard SM, Razak K, Ethell IM. 2015. A delicate balance: role of MMP-9 in brain development and pathophysiology of neurodevelopmental disorders. Front Cell Neurosci. 9:280.


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